A clinical retrospective study was undertaken in 81 patients with acute pyelonephritis admitted to the Department of Internal Medicine, Chungnam National University Hospital from January 1983 to December 1989.
The results were as follows：
1. Total number of patients studied was 81(M/F ratio, 1： 4.4). The M/F ratio of 22 complicated patients(27.2％) was 1： 2.7
2. The predisposing factors associated with complicated patients were as follows：7 cases of urinary tract stone, 7 cases of pregnancy, 4 cases of neurogenic bladder and each one case of prostatic hypertrophy, ureter cancer, bladder diverticulum and polycystic kidney disease.
3. The common subjective symptoms on admission were fever and chills, frank pain, nausea and vomiting. High body temperature and CVA tenderness were noted in 61％ and 95％ of patients respectively. And 50.6％ of patients revealed right CVA tenderness and 28.4％ in left, 16％ in both respectively. There was no difference in symptoms and signs between complicated and uncomplicated groups
4. In 50 patients(61.7％) microorganisms were isolated on the urine culture specimens. The most common orga ｀nism was E. coli(80％ ), and followed by Staphylococcus aureus and Serratia odorifera. E coli was the most frequent pathogen in both female and male patients, and in complicated and uncomplicated groups. (In sensitivity test of complicated and uncomplicated groups). In sensitivity test of causative pathogens to antibiotics, E coli was sensitive to amikacin(93％), tobramycin(83.3％) and gentamycin(79.4％) and 88.9 percent of E coli were ressistant to ampicillin
5. In urinary examination on admission, pyuria was noted in 81％ of patients, and proteinuria and microscopic hematuria were noted in 68％ and 44％ of patients respectively.
6. Within 3 days after antibiotics treatment deference was occured in 73.5％ of total patients, and complicated patients revealed delayed defeverence compared to uncomplicated ones.
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